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XMAS – Cross-Modality Annotation Software

A smarter way to annotate retinal images.

XMAS is an advanced software tool built to streamline retinal image annotation across multiple imaging modalities, all in one interface. Designed for researchers, clinicians, and AI developers, XMAS enables precise, synchronized annotation and visualization of images from OCT, fundus, autofluorescence, hyperspectral imaging, and more.

Why XMAS?

✅ Multi-modal visualisation
View and annotate multiple imaging types simultaneously,  from en-face to B-scan.

✅ Automated image alignment
Built-in co-registration tools align images from different modalities with pixel-level accuracy.

✅ Efficient annotation workflow
Use smart tools for pixel painting, shape drawing, retinal layer mapping, and deep learning-based vessel segmentation.

✅ Collaborative features
Work in teams with version control, comment threads, and annotation tracking for every case.

✅ AI-ready exports
Structured annotation outputs ready for statistical analysis or training deep learning models.

Used in Leading Research

  • Saeed A, Guymer RH, Hadoux X, Jannaud M, Dang D, Hodgson LAB, et al. Customized Evaluation of Progressive Visual Sensitivity Loss in Geographic Atrophy to Improve the Power of Clinical Trials. Ophthalmol Sci. 2025;5(4):100763.
  • Wu Z, Hadoux X, Jannaud M, Glover EK, Gee EE, Hodgson LAB, et al. Visual Sensitivity Loss in Geographic Atrophy: Structure-Function Evaluation Using Defect-Mapping Microperimetry. Invest Ophthalmol Vis Sci. 2024;65(1):36.
  • Saeed A, Guymer RH, Hadoux X, Jannaud M, Dang D, Hodgson LAB, et al. Longitudinal Changes of Visual Sensitivity With Geographic Atrophy Progression Assessed by Defect-Mapping Microperimetry. Invest Ophthalmol Vis Sci. 2024;65(14):13.
  • Kumar H, Guymer RH, Hodgson LAB, Hadoux X, Jannaud M, van Wijngaarden P, et al. Reticular Pseudodrusen: Impact of Their Presence and Extent on Local Rod Function in Age-Related Macular Degeneration. Ophthalmol Sci. 2024;4(6):100551.
  • Greig EC, Moult EM, Despotovic IN, Hodgson LAB, Pramil V, Fujimoto JG, et al. Assessment of Choriocapillaris Flow Prior to Nascent Geographic Atrophy Development Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2024;65(1):33.
  • Goh KL, Wintergerst MWM, Abbott CJ, Hadoux X, Jannaud M, Kumar H, et al. Hyperreflective Foci Not Seen as Hyperpigmentary Abnormalities on Color Fundus Photographs in Age-Related Macular Degeneration. Retina. 2024;44(2):214-21.
  • Goh KL, Kumar H, Hadoux X, Jannaud M, Abbott C, Hodgson L, et al. Hyperpigmentary abnormalities in age-related macular degeneration: association with progression and impact on visual sensitivity. Br J Ophthalmol. 2024;108(2):263-7.
  • Wu Z, Zhou X, Chu Z, Gregori G, Wang RK, Rosenfeld PJ, Guymer RH. Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2022;63(12):1.
  • Goh KL, Abbott CJ, Hadoux X, Jannaud M, Hodgson LAB, van Wijngaarden P, et al. Hyporeflective Cores within Drusen: Association with Progression of Age-Related Macular Degeneration and Impact on Visual Sensitivity. Ophthalmol Retina. 2022;6(4):284-90.